Purple corn, known as Zea mays L.(variety Kculli Peruvians), has been widely utilized as Natural food colorant. Purple corn color rich in anthocyanins and functional phenolics has attenuating effects on hypertension, diabetes and cancer as potential medicinal uses In our previous studies purple corn anthocyanins retarded diabetes-associated glomerular inflammation and glomerulosclerosis.Based on the possible anti-angiogenic activity of anthocyanins, this study investigated whether Anthocyanins-rich purple corn extract (PCE) inhibited excessive blood vessel formation and endothelial proliferation in the early stage of diabetic kidney glomeruli. This study examined whether PCE suppressed the induction of angiogenic factors of VEGF, HIF-1α, Angpt and Tie-2 in endothelial cells cultured in high glucose-exposed mesangial conditioned media (HG-HRMC-CM) and in db/db mice. VEGF receptor 2 (VEGFR2), platelet endothelial cell adhesion molecule (PECAM-1) and Ki-67 were also determined for the anti-angiogenic activity of PCE. Furthermore, endothelial tube formation and aorta ring assay were performed for the PCE antagonism of diabetes-triggered glomerular angiogenesis.
Purple corn may be a potent therapeutic agent for the treatment for diabetes-associated glomerulosclerosis accompanying proteinuria and kidney filtration dysfunction.Anthocyanins have been shown to exhibit anti-carcinogenic activity against multiple cancer cell types in vitroand tumor types in vivo. Potential cancer chemopreventive activities of anthocyanins revealed from in vitrostudies include radical scavenging activity, stimulation of phase II detoxifying enzymes, reduced cell proliferation, inflammation, angiogenesis and invasiveness, and induction of apoptosis and differentiation. The anthocyanins modulate the expression and activation of multiple genes associated with these cellular functions including genes involved in the PI3K/Akt, ERK, JNK, and MAPK pathways . In vivostudies have shown that dietary anthocyanins inhibit cancers of the gastrointestinal (G.I.) tract and topically applied anthocyanins inhibit skin cancer. Pharmacokinetic data indicate that the absorption of anthocyanins into the bloodstream of rodents and humans is minimal, suggesting that they may have little efficacy in tissues other than the G.I. tract and skin, where they can be absorbed locally. Measuring tissue-bound anthocyanins should be done to predict the chemopreventive effects of anthocyanins in different organ sites. The role of gut bacteria in the metabolism and uptake of anthocyanins should also be investigated. Finally, studies should be undertaken to determine if the anti-cancer effects of anthocyanins are due to the parent compounds and/or to their metabolites.
Product Characteristic: Powder System. MOQ: 10 Kg/50Kg/100 Kg/1MT.
Package: Laminated Bags Plastics./Box: 10Kg.